In Mice Anti-Inflammatories Ameliorate Medical Marijuana's Memory Mishaps
在老鼠實驗中，消炎藥改善了藥用大麻對記憶的損傷(災難、不幸)
Medical marijuana can interfere with memory and learning, but mice that got pot and anti-inflammatories avoided the detrimental effects. Sophie Bushwick reports
藥用大麻會干擾記憶力與學習，但是老鼠有了大麻與消炎藥便可避免這樣有害的影響。
文章出處:
http://www.scientificamerican.com/podcast/episode.cfm?id=in-mice-anti-inflammatories-amelior-13-11-21
Medical marijuana helps treat disorders such as chronic pain, nausea and seizures. Unfortunately, it can also...um...oh yeah, it can also impair memory and learning. But a new study suggests we can prevent this side effect with easily available medication.
藥用大麻可用來治療像是慢性疼痛、噁心與疾病驟發(通常是指心臟病)等不適。
但不幸的是，它也會造成...嗯...噢!對了!它也會造成記憶力與學習能力的損害。
不過，有新的研究顯示，我們可以利用容易取得的藥物來避免這樣的副作用。
The problem stems from the hippocampus, the brain region responsible for memory formation. So scientists exposed mice to THC, the psychoactive chemical in cannabis, and then looked at their brains. They noticed that the hippocampi of the treated mice produced higher levels of an enzyme called COX-2. When the researchers administered drugs that reduced levels of COX-2, the memory problems disappeared as well. As did some neuron damage.
(副作用的)問題是來自於海馬迴，這個大腦的區塊掌管著記憶的形成。
因此，科學家讓老鼠暴露在四氫大麻酚(大麻中的主要有毒致幻成分)中，
其為大麻中對心理或精神有顯著影響的化學成分，接著再觀察牠們的大腦。科學家發現暴露在四氫大麻酚中的老鼠，
牠們的海馬迴會大量的製造出叫做環氧化酶-二(受發炎而誘發的酵素)的一種酵素。
當研究者將用來減少環氧化酶-二的藥物給老鼠服用後，
記憶力(受損)的問題也就消失了。隨之有一些神經元也的確受損了。
But protecting the brain against memory loss did not seem to stop the positive effects of marijuana.
而且，保護大腦免受記憶力衰退，似乎也不會讓大麻的正面效用停止作用。
The scientists used cannabis to treat a mouse model of Alzheimer's disease. Whether or not they inhibited COX-2, pot appeared to be beneficial. The work is in the journal Cell. [Chen et al., Δ9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling]
科學家還將大麻用來治療患有阿茲海默症的老鼠。且不論他們是否有抑制環氧化酶-二，大麻似乎是有益的。這份研究刊登於"細胞"期刊。
[四氫大麻酚( Δ9-THC =THC)所造成的突觸與記憶損傷可透過環氧化酶-二的信號來調解]
(身體不適 —> 注入四氫大麻酚 —> 海馬迴產出環氧化酶-二 —> 注入環氧化酶-二抑制劑 —> 避免記憶力損傷+減緩不適)
Drugs that block COX-2 include anti-inflammatories, such as over-the-counter painkiller ibuprofen. But before you start self-medicating, you might want to wait for confirmation in people.
可封鎖環氧化酶-二(產出)還可抗發炎的藥物有，像是止痛成藥普羅芬(非類固醇消炎藥)。但在你開始自行使用藥物治療之前，或許該等到這已證實可於人類食用且有效無虞。
—Sophie Bushwick
